Bacteria have developed an impressive ability to survive and propagate in highly diverse and changing environments by evolving phenotypic heterogeneity. Phenotypic heterogeneity ensures that a subpopulation is well prepared for environmental changes. The expression bet hedging is commonly (but often incorrectly) used by molecular biologists to describe any observed phenotypic heterogeneity. In evolutionary biology, however, bet hedging denotes a risk‐spreading strategy displayed by isogenic populations that evolved in unpredictably changing environments. Opposed to other survival strategies, bet hedging evolves because the (...) selection environment changes and favours different phenotypes at different times. Consequently, in bet hedging populations all phenotypes perform differently well at any time, depending on the selection pressures present. Moreover, bet hedging is the only strategy in which temporal variance of offspring numbers per individual is minimized. Our paper aims to provide a guide for the correct use of the term bet hedging in molecular biology. (shrink)

Institutional theory of law (ITL) reflects both continuity and change of Kelsen's legal positivism. The main alteration results from the way ITL extends Hart's linguistic turn towards ordinary language philosophy (OLP). Hart holds – like Kelsen – that law cannot be reduced to brute fact nor morality, but because of its attempt to reconstruct social practices his theory is more inclusive. By introducing the notion of law as an extra-linguistic institution ITL takes a next step in legal positivism and accounts (...) for the relationship between action and validity within the legal system. There are, however, some problems yet unresolved by ITL. One of them is its theory of meaning. An other is the way it accounts for change and development. Answers may be based on the pragmatic philosophy of Charles Sanders Peirce, who emphasises the intrinsic relation between the meaning of speech acts and the process of habit formation. (shrink)

Depletion of mitochondrial endo/exonuclease G‐like (EXOG) in cultured neonatal cardiomyocytes stimulates mitochondrial oxygen consumption rate (OCR) and induces hypertrophy via reactive oxygen species (ROS). Here, we show that neurohormonal stress triggers cell death in endo/exonuclease G‐like‐depleted cells, and this is marked by a decrease in mitochondrial reserve capacity. Neurohormonal stimulation with phenylephrine (PE) did not have an additive effect on the hypertrophic response induced by endo/exonuclease G‐like depletion. Interestingly, PE‐induced atrial natriuretic peptide (ANP) gene expression was completely abolished in endo/exonuclease (...) G‐like‐depleted cells, suggesting a reverse signaling function of endo/exonuclease G‐like. Endo/exonuclease G‐like depletion initially resulted in increased mitochondrial OCR, but this declined upon PE stimulation. In particular, the reserve capacity of the mitochondrial respiratory chain and maximal respiration were the first indicators of perturbations in mitochondrial respiration, and these marked the subsequent decline in mitochondrial function. Although pathological stimulation accelerated these processes, prolonged EXOG depletion also resulted in a decline in mitochondrial function. At early stages of endo/exonuclease G‐like depletion, mitochondrial ROS production was increased, but this did not affect mitochondrial DNA (mtDNA) integrity. After prolonged depletion, ROS levels returned to control values, despite hyperpolarization of the mitochondrial membrane. The mitochondrial dysfunction finally resulted in cell death, which appears to be mainly a form of necrosis. In conclusion, endo/exonuclease G‐like plays an essential role in cardiomyocyte physiology. Loss of endo/exonuclease G‐like results in diminished adaptation to pathological stress. The decline in maximal respiration and reserve capacity is the first sign of mitochondrial dysfunction that determines subsequent cell death. (shrink)

In angiosperms cytoplasmic DNA is typically passed on maternally through ovules. Genes in the mtDNA may cause male sterility. When male-sterile (female) cytotypes produce more seeds than cosexuals, they pass on more copies of their mtDNA and will co-occur with cosexuals with a neutral cytotype. Cytoplasmic gynodioecy is a well-known phenomenon in angiosperms, both in wild and crop plants. In some conifer families (e.g. Pinaceae) mitochondria are also maternally inherited. However in some other families (e.g. Taxaceae and Cupressaceae) mtDNA is (...) paternally inherited through the pollen. With paternal mtDNA inheritance, male cytotypes that produce more pollen than cosexuals are expected to co-occur with cosexuals. This is uncharted territory. An ESS model shows that the presence of male cytotypes selects for more female allocation in the cosexual, i.e. for sexual specialisation. An allele that switches sex from male to female can then invade. This leads to rapid loss of the neutral cytotype of the cosexual, fixation of the male cytotype and dioecy with 50% males and 50% females. The models suggest that paternal inheritance of mtDNA facilitates the evolution dioecy. Consistent with this hypothesis the Pinaceae are 100% monoecious, while dioecy is common in the Taxaceae family and in the genus Juniperus (Cupressaceae). However, no reliable data are yet available on both mode of inheritance of mtDNA and gender variation of the same species. When cosexuals benefit from reproductive assurance (high selfing rate, low inbreeding depression, low fertilisation) they maintain themselves next to males and females. This predicted pattern with three sex types present in the same population is observed in conifers in nature. (shrink)

One in three university students experiences mental health problems during their study. A similar percentage leaves higher education without obtaining the degree for which they enrolled. Research suggests that both mental health problems and academic underperformance could be caused by students lacking control and purpose while they are adjusting to tertiary education. Currently, universities are not designed to cater to all the personal needs and mental health problems of large numbers of students at the start of their studies. Within the (...) literature aimed at preventing mental health problems among students (e.g., anxiety or depression), digital forms of therapy recently have been suggested as potentially scalable solutions to address these problems. Integrative psychological artificial intelligence (AI) in the form of a chatbot, for example, shows great potential as an evidence-based solution. At the same time, within the literature aimed at improving academic success, the online life-crafting intervention in which students write about values and passions, goals, and goal-attainment plans has shown to improve the academic performance and retention rates of students. Because the life-crafting intervention is delivered through the curriculum and doesn’t bear the stigma that is associated with therapy, it can reach larger populations of students. But life-crafting lacks the means for follow-up or the interactiveness that online AI-guided therapy can offer. In this paper, we propose to integrate the current literature on chatbot interventions aimed at the mental health of students with research about a life-crafting intervention that uses an inclusive curriculum-wide approach. When a chatbot asks students to prioritize both academic as well as social and health-related goals and provides personalized follow-up coaching, this can prevent -often interrelated- academic and mental health problems. Right on-time delivery, and personalized follow-up questions enhance the effects of both -originally separated- intervention types. Research on this new combination of interventions should use design principles that increase user-friendliness and monitor the technology acceptance of its participants. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

© 2016 Regents of the University of California.The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,062 new measurements from 721 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. All the particle properties and search limits are listed in Summary Tables. We also give numerous (...) tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 117 reviews are many that are new or heavily revised, including those on Pentaquarks and Inflation. The complete Review is published online in a journal and on the website of the Particle Data Group. The printed PDG Book contains the Summary Tables and all review articles but no longer includes the detailed tables from the Particle Listings. A Booklet with the Summary Tables and abbreviated versions of some of the review articles is also available. (shrink)

The shift in the prevailing view of alcoholism from a moral paradigm towards a biomedical paradigm is often characterized as a form of biomedicalization. We will examine and critique three reasons offered for the claim that viewing alcoholism as a disease is morally problematic. The first is that the new conceptualization of alcoholism as a chronic brain disease will lead to individualization, e.g., a too narrow focus on the individual person, excluding cultural and social dimensions of alcoholism. The second claim (...) is that biomedicalization will lead to stigmatization and discrimination for both alcoholics and people who are at risk of becoming alcoholics. The third claim is that as a result of the biomedical point of view, the autonomy and responsibility of alcoholics and possibly even persons at risk may be unjustly restricted. Our conclusion is that the claims against the biomedical conceptualization of alcoholism as a chronic brain disease are neither specific nor convincing. Not only do some of these concerns also apply to the traditional moral model; above that they are not strong enough to justify the rejection of the new biomedical model altogether. The focus in the scientific and public debate should not be on some massive “biomedicalization objection” but on the various concerns underlying what is framed in terms of the biomedicalization of alcoholism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Did Hobbes Have a Semantic Theory of Truth? WILLEM R. DEJONG 1. INTRODUCTION THE qUESTIONRAISEDin the title of this article may strike the reader as a bit anachronistic. A phrase like 'semantic theory of truth' evokes associations with rather recent developments in logic, especially the work of Alfred Tarski. Nevertheless, it is generally agreed that Hobbes made important observations of a semantical nature. Moreover, in an interesting article still (...) frequently referred to, R. M. Martin has argued that Hobbes "has in mind a clear-cut semantical concept of truth."' Examining Hobbes's semantical ideas somewhat more closely than Martin did, T6rnebohm has given a more precise characterization of Hobbes's view on truth and falsity; he speaks of Hobbes's comprehension theory of truth. ~One of the main purposes of this article is to investigate whether such a theory is correctly attributed to Hobbes. For Tarski 'true' and 'false' are predicates of (declarative) sentences) But this is not enough to speak of a semantic theory of truth: The leading idea behind Tarski's fundamental work in the field of semantics is (a restricted version of) the principle of compositionality. This principle, also known as Frege's principle, says that the semantic value of a (complex) expression is a function of the semantic values of the syntactic (and categorematic) parts it is ' R. M. Martin, "On the Semantics of Hobbes," Philosophyand PhenomenologicalResearch 14 095314): 2o5-11, esp. ~o7, 211. Cf. I. C. Hungerland and G. R. Vick, "Hobbes's Theory of Language, Speech and Reasoning," in ThomasHobbes:Computatwsire Logica--Logic, translated and commentary by A. Martinich, ed. and introduced by I. C. Hungerland and G. R. Vick (New York: 1981), 15--167, esp. 17, 121-22. 9 H. T6rnebohm, "A Study in Hobbes' Theory of Denotation and Truth," Theor~a26 (196o): 53-7o; see p. 66. 3 A. Tarski, "The Semantic Conception of Truth and the Foundations of Semantics," Philosophy and PhenomenologicalResearch4 (1944): 341-375; see p. 342. [63] 64 JOURNAL OF THE HISTORY OF PHILOSOPHY 28:1 JANUARY 199o composed of. Moreover, in the case of linguistic expressions which are (deciarative ) sentences this semantic value should be its truth-value. 4 As we shall see, Hobbes's theory of propositions is basically a theory of subject-predicate propositions. It is therefore reasonable to qualify his theory of truth as a semantic one only if it satisfies Frege's principle to a certain extent. Ideally, this means that the truth-value of subject-predicate propositions should be conceived as a function of the semantic interpretations of its subject and predicate. In the next three sections I will concentrate principally on the logicosyntactical aspects of language. I will then discuss successively the general structure of propositions, the various sorts of names, and the syntax of Hobbes's theory of propositions. Section 5 is devoted to Hobbes's theory of truth as interpreted by Martin and T0rnebohm. The outcome of this examination makes it necessary to break away from Martin's restricted conception of semantics. Martin, like Tarski, takes semantics as "semantics in the narrower sense," i.e., as the discipline Quine refers to as the theory of reference. 5 However, sometimes this term is used in a broader sense; the field of semantics is taken then to include the theory of meaning too. Although the wording differs frequently, the distinction between meaning and reference is almost a constant in the history of thinking about language. On the side of meaning one finds terms like connotation, intension, conception, signification and analyticity, while terms like naming, denoting, extension (and sometimes again signification) are ]inked to the notion of reference. In the Computatio sive Logica, the first part of De Corpore, containing Hobbes's most mature work on the philosophy of language, this opposition is displayed by way of a distinction between, on the one side, nominare, denotare and appellare and, on the other side, significare. Hobbes's view of the significative, as opposed to the denotative, role of linguistic expressions is treated in sections 6, 7, and 8. There it will be shown that Hobbes's radical nominalism is decisive for his doctrine of signification; moreover, this nominalism raises serious problems for the relation... (shrink)

Review of Johan de Jong, The Movement of Showing: Indirect Method, Critique, and Responsibility in Derrida, Hegel, and Heidegger (New York: SUNY, 2020).

Automated technologies and robots make decisions that cannot always be fully controlled or predicted. In addition to that, they cannot respond to punishment and blame in the ways humans do. Therefore, when automated cars harm or kill people, for example, this gives rise to concerns about responsibility-gaps and retribution-gaps. According to Sven Nyholm, however, automated cars do not pose a challenge on human responsibility, as long as humans can control them and update them. He argues that the agency exercised in (...) automated cars should be understood in terms of human–robot collaborations. This brief note focuses on the problem that arises when there are multiple people involved, but there is no obvious shared collaboration among them. Building on John Danaher’s discussion of command responsibility, it is argued that, although Nyholm might be right that autonomous cars cannot be regarded as acting on their own, independently of any human beings, worries about responsibility-gaps and retribution-gaps are still justified, because it often remains unclear how to allocate or distribute responsibility satisfactorily among the key humans involved after they have been successfully identified. (shrink)

This paper analyses the relationship between Hobbes's theory of language and his theory of science and method. It is shown that Hobbes, at least in his Computatio sive Logica (1655), deviates in some measure from the traditional (Aristotelian) model of language. In this model speech is considered to be a fairly unproblematic expression of thought, which itself is independent of language. Basing himself on a nominalist account of universals, Hobbes states that the demonstration or assertion of universal propositions presupposes speech (...) (more especially, the use of names as marks). This insight turns out to be essential for Hobbes's (rationalist) view of scientific method. (shrink)

It is not easy being green, but it does beg the question: Does being green pay off on the bottom-line? Unfortunately, that question of becoming ISO 14001 to reap financial benefit remains widely unanswered. In particular, corporate practice is interested in how environmental management impacts firms’ finance through top-line impact, bottom-line impact, or both—as this paves the way for an investment of environmental management. As current findings are mixed, our study tracks financial performance of publicly traded US firms between 1996 (...) and 2005 to test whether ISO 14001 leads to improved financial performance. Employing a rigorous event-study approach, we compare certified firms to different control groups based on several matching criteria that include industry, size, and/or ROA. In the short run, ISO 14001 certification makes only a minor impact on the bottom-line, according to our results. However, these same results show a significant financial improvement over the long haul with ISO 14001 certification. Additionally, this long-term improvement also makes a significant improvement in top-line performance. Thus, we conclude that environmental management pays off along both dimensions. (shrink)

Kant's distinction between analytic and synthetic method is connected to the so-called Aristotelian model of science and has to be interpreted in a (broad) directional sense. With the distinction between analytic and synthetic judgments the critical Kant did introduced a new way of using the terms 'analytic'-'synthetic', but one that still lies in line with their directional sense. A careful comparison of the conceptions of the critical Kant with ideas of the precritical Kant as expressed in _Ãœber die Deutlichkeit, leads (...) to the interpretation defended here of Kant's distinction between analytic and synthetic judgments within his philosophy of mathematics. (shrink)

John Bickle's new book on philosophy and neuroscience is aptly subtitled ‘a ruthlessly reductive account’. His ‘new wave metascience’ is a massive attack on the relative autonomy that psychology enjoyed until recently, and goes even beyond his previous (Bickle, J. (Citation1998). Psychoneural reduction: The new wave. Cambridge, MA: MIT Press.) new wave reductionsism. Reduction of functional psychology to (cognitive) neuroscience is no longer ruthless enough; we should now look rather to cellular or molecular neuroscience at the lowest possible level for (...) explanations of memory, consciousness and attention. Bickle presents a fascinating set of experimental cases of such molecule-to-mind explanations. This book qualifies as a showcase of naturalism in the philosophy of mind. Naturally, many of the traditional conceptual approaches in the philosophy of mind are given short shrift, but—in Bickle's metascientific scheme—the role of philosophy of science also seems reduced to explicating laboratory findings. The present reviewers think that this reductionism suffers from overstretching; in particular, the idea of ‘explanation in a single bound’ from molecule to mind is a bit too ruthless. Still, Bickle's arguments are worth serious attention. (shrink)

In this series of papers I attempt to provide an answer to the question how the Babylonian scholars arrived at their mathematical theory of planetary motion. Papers I and II were devoted to system A theory of the outer planets and of the planet Venus. In this third and last paper I will study system A theory of the planet Mercury. Our knowledge of the Babylonian theory of Mercury is at present based on twelveEphemeridesand sevenProcedure Texts. Three computational systems of (...) Mercury are known, all of system A. System A1is represented by nineEphemeridescovering the years 190 BC to 100 BC and system A2by twoEphemeridescovering the years 310 to 290 BC. System A3is known from aProcedure Textand from Text M, anEphemerisof the last evening visibility of Mercury for the years 424 to 403 BC. From an analysis of the Babylonian observations of Mercury preserved in theAstronomical DiariesandPlanetary Textswe find: (1) that dates on which Mercury reaches its stationary points are not recorded, (2) that Normal Star observations on or near dates of first and last appearance of Mercury are rare (about once every twenty observations), and (3) that about one out of every seven pairs of first and last appearances is recorded as “omitted” when Mercury remains invisible due to a combination of the low inclination of its orbit to the horizon and the attenuation by atmospheric extinction. To be able to study the way in which the Babylonian scholars constructed their system A models of Mercury from the available observational material I have created a database of synthetic observations by computing the dates and zodiacal longitudes of all first and last appearances and of all stationary points of Mercury in Babylon between 450 and 50 BC. Of the data required for the construction of an ephemeris synodic time intervals Δt can be directly derived from observed dates but zodiacal longitudes and synodic arcs Δλ must be determined in some other way. Because for Mercury positions with respect to Normal Stars can only rarely be determined at its first or last appearance I propose that the Babylonian scholars used the relation Δλ = Δt −3;39,40, which follows from the period relations, to compute synodic arcs of Mercury from the observed synodic time intervals. An additional difficulty in the construction of System A step functions is that most amplitudes are larger than the associated zone lengths so that in the computation of the longitudes of the synodic phases of Mercury quite often two zone boundaries are crossed. This complication makes it difficult to understand how the Babylonian scholars managed to construct System A models for Mercury that fitted the observations so well because it requires an excessive amount of computational effort to find the best possible step function in a complicated trial and error fitting process with four or five free parameters. To circumvent this difficulty I propose that the Babylonian scholars used an alternative more direct method to fit System A-type models to the observational data of Mercury. This alternative method is based on the fact that after three synodic intervals Mercury returns to a position in the sky which is on average only 17.4° less in longitude. Using reduced amplitudes of about 14°–25° but keeping the same zone boundaries, the computation of what I will call 3-synarc system A models of Mercury is significantly simplified. A full ephemeris of a synodic phase of Mercury can then be composed by combining three columns of longitudes computed with 3-synarc step functions, each column starting with a longitude of Mercury one synodic event apart. Confirmation that this method was indeed used by the Babylonian astronomers comes from Text M (BM 36551+), a very early ephemeris of the last appearances in the evening of Mercury from 424 to 403 BC, computed in three columns according to System A3. Based on an analysis of Text M I suggest that around 400 BC the initial approach in system A modelling of Mercury may have been directed towards choosing “nice” sexagesimal numbers for the amplitudes of the system A step functions while in the later final models, dating from around 300 BC onwards, more emphasis was put on selecting numerical values for the amplitudes such that they were related by simple ratios. The fact that different ephemeris periods were used for each of the four synodic phases of Mercury in the later models may be related to the selection of a best fitting set of System A step function amplitudes for each synodic phase. (shrink)

Fenomenologie van het proces van bewijzen in strafzaken In deze bijdrage staat de activiteit van bewijzen in strafzaken centraal. Betoogd wordt dat de vigerende rationalistische opvatting van strafrechtelijk bewijzen eraan voorbij gaat dat het bewijzen zich allereerst voltrekt op een vóór-reflectief niveau. Het primaire blikveld van de mens is namelijk niet het objectiverende kennen, zoals in de rationele bewijstheorieën wordt voorondersteld, maar de praktische relatie tot de wereld. In dit kader wordt eerst de filosofische achtergrond van de rationalistische bewijsopvatting in (...) kaart gebracht, in het bijzonder de invloed van Aristoteles en Descartes. Vervolgens worden de daaruit voortkomende bevindingen aan de hand van ideeën en inzichten die zijn ontleend aan de existentiële fenomenologie kritisch gewaardeerd. Dit leidt tot de uiteenzetting van een hermeneutische opvatting van strafrechtelijk bewijzen. (shrink)

This paper explores the management of societal impact in the context of Horizon 2020 (H2020) Social Sciences and Humanities (SSH) collaborative projects. Given the increasing demand for societal relevance in European-funded research, this study aims to (a) understand how societal impact is managed and (b1) identify the driving forces and (b2) barriers that influence impact management. By conducting semi-structured interviews with ten project coordinators from different European SSH projects, selected through purposive sampling procedures, the collected qualitative data were analysed using (...) Atlas.ti. The thematic analysis revealed six themes: effective framework, stakeholder involvement; appropriate dissemination, competence, diversity and experienced members, limited post-project impact resources; and ineffective planning. This paper contributes to the discourse on project management by proposing a refined evaluation framework for societal impact that recognises different management strategies and considers the need for strategic planning and resource allocation to achieve sustainable societal impact. Our findings advocate for policies that promote greater transparency and inclusiveness in project evaluation, ultimately aiming to better align research outcomes with European policy priorities and societal challenges. (shrink)

Domestic violence is a serious issue, and the costs for business of failing to address the impacts of domestic violence in the workplace are high. New technologies and economic shifts towards services sector industries are fast dissolving the boundaries between the workplace and the home in many national labor markets. Moreover, companies are now expected to meet higher standards of behavior in fulfilling their responsibilities to employees and wider society. These developments present challenges for ethical reasoning about the limits of (...) employer responsibility in relation to domestic violence. While a number of possible approaches have something to contribute, this paper argues that feminist theories provide the most useful framework for ethical reasoning about the issues domestic violence raises for business organizations. The practical value of such reasoning is then illustrated by applying the organizing framework developed by Yuan et al. to examine how recurring domestic violence-related initiatives can be integrated as routine practices in firm operations. The paper thus provides a structured qualitative study of theory and practice for dealing with the impacts of domestic violence in the workplace. (shrink)

The present volume, a tribute to Harry Dondorp, contains contributions to the symposium held on the occasion of his farewell at the Vrije Universiteit Amsterdam. Written by four eminent scholars in the field of legal history, the contributions are related to his areas of interest: delictual liability, Romano-canonical procedure and comparative law texts. The contributors are Wolfgang Ernst, David Ibbetson, Yves Mausen and Andreas Thier. The introductory words are by Eltjo Schrage, Jan Hallebeek and Hylkje de Jong.

Social robots progressively enter children’s lives, but little is known about children’s acceptance of social robots and its antecedents. To fill this research gap, this narrative review surveyed 34 articles on child-robot interaction published between 2000 and 2017. We focused on robot, user, and interaction characteristics as potential antecedents of children’s intentional and behavioral social robot acceptance. In general, children readily accept robots. However, we found that social, adaptive robot behavior, children’s sex and age, as well as frequency of the (...) interaction seem to affect acceptance. Additionally, we found various theoretical and methodological shortcomings in the field. The review concludes with recommendations and directions for future research on children’s acceptance of social robots. (shrink)

The need for urgent, structural transformations to dominant food systems is increasingly recognized in research and policy. The direction these transformations take is in great part influenced by how the problem is framed and what future pathways become seen as plausible and desirable. Scientific knowledge and the organizations producing it hold considerable authority in suggesting what alternatives are or are not worth pursuing, ultimately shaping frames and in turn being shaped by them. This paper examines Brazil’s federal Agricultural Research Corporation (...) (Embrapa), a major contributor to technological advances that made Brazil into an agricultural powerhouse. We examine the ways in which Embrapa’s leadership has framed sustainable agriculture in its public communication and the wider implications for food systems transformation. Drawing from Embrapa news articles in the period 2015–2020, we identify four interrelated frames forming Embrapa’s prevalent position on sustainability. Our results show that while Embrapa promotes practices based on alternative approaches such as agroecology, its deeper framing often reflects the core assumptions driving dominant industrial food systems. This framing reinforces underlying logics of control, efficiency, and competition aligned with the productivist paradigm and excludes divergent perspectives that exist within the organization. (shrink)

With his doctrine of the “complete irresponsibility of man,” Nietzsche in different ways complicates the opposition between responsibility and irresponsibility. This article traces the different and conflicting senses of irresponsibility throughout Nietzsche’s development. First, the doctrine is shown to build on Nietzsche’s early study of Heraclitus (section I), whom Nietzsche admired for expounding and embodying a radical “innocence” that was both responsible and irresponsible in different senses. When presented as “philosophical conviction” in Human, All too Human, Nietzsche paradoxically speculates about (...) the doctrine’s incorporation out of a sense of responsibility for the future of mankind (section II). Section III shows how Nietzsche’s later writings evince an increasing awareness of this paradox by explicitly positing complete irresponsibility as his own redemptive doctrine in Twilight of the Idols. After 1881, he has come to affirm a new notion of responsibility and criticizes a weak sense of irresponsibility as the abdication of one’s task. I end by discussing the relation of these different senses of irresponsibility, and argue that the fact that Nietzsche’s texts often deliberately complicate rather than clarify such distinctions is an important reflection of how he textually takes responsibility for “complete irresponsibility” (section IV). (shrink)

The International Conference on Cognitive Modeling brings together researchers from around the world whose main goal is to build computational systems that reflect the internal processes of the mind. In this issue, we present the five best representative papers on this work from our 19th meeting, ICCM 2021, which was held virtually from July 3 to July 9, 2021. Three of these papers provide new techniques for refining computational models, giving better methods for taking empirical data and producing accurate computational (...) models of the cognitive systems that produce them. The other two papers focus on explanation: using models to elucidate the underlying processes affecting cognition in such diverse domains as logical reasoning and the effects of caffeine. (shrink)

The advent of new genetic and genomic technologies may cause friction with the principle of respect for autonomy and demands a rethinking of traditional interpretations of the concept of informed consent. Technologies such as whole‐genome sequencing and micro‐array based analysis enable genome‐wide testing for many heterogeneous abnormalities and predispositions simultaneously. This may challenge the feasibility of providing adequate pre‐test information and achieving autonomous decision‐making. At a symposium held at the 11th World Congress of Bioethics in June 2012 (Rotterdam), organized by (...) the International Association of Bioethics, these challenges were presented for three different areas in which these so‐called ‘new genetics’ technologies are increasingly being applied: newborn screening, prenatal screening strategies and commercial personal genome testing. In this article, we build upon the existing ethical framework for a responsible set‐up of testing and screening offers and reinterpret some of its criteria in the light of the new genetics. As we will argue, the scope of a responsible testing or screening offer should align with the purpose(s) of testing and with the principle of respect for autonomy for all stakeholders involved, including (future) children. Informed consent is a prerequisite but requires a new approach. We present preliminary and general directions for an individualized or differentiated set‐up of the testing offer and for the informed consent process. With this article we wish to contribute to the formation of new ideas on how to tackle the issues of autonomy and informed consent for (public) healthcare and direct‐to‐consumer applications of the new genetics. (shrink)

What happens to representative democracy when populism comes to power? How does populism in power transform or disfigure the procedures and institutions of representative democracy? These are the c...